2016 Best New Radiology Device! Extremity Cone-Beam CT

October 26, 2016

The winner of the 2016 Best New Radiology Device from Aunt Minnie this year began as an industry collaboration betewen Johns Hopkins University  and Carestream Health that eventually evolved into a commercial product. The system also won the 2016 Frost & Sullivan Award for New Product Innovation.

OnSight 3D is designed to bring advanced 3D imaging to orthopaedic surgeons, musculoskeletal radioloigsts, and rheumatologists. The system allows high-resolution imaging of the extremities, including weight-bearing lower extremities. It also features image processing algorithms for fast 3D image reconstruction, rendering, metal artifact reduction, and image analysis.

Tharindu DeSilva reports clinical utility of LevelCheck.

The “LevelCheck” algorithm for automatic radiographic labeling of the spine during surgery was evaluated by Tharindu De Silva and colleagues in a recent paper published in Spine. The clinical utility was assessed, and scenarios in which LevelCheck was most likely to be the beneficial were assessed in a retrospective study of 398 cases.

The results showed that LevelCheck was helpful in 42.2% of the cases (168/398), to improved confidence in 30.6% of the cases (122/398), and in no case diminished performance (0/398), supporting its potential as an independent check and assistant to decision support in spine surgery.

The scenarios for which LevelCheck was most likely to be beneficial included: cases with a lack of conspicuous anatomical landmarks; level counting across long spine segments; vertebrae obscured by other anatomy (e.g., shoulders); poor radiographic image quality; and anatomical variations/abnormalities.

The method demonstrated 100% geometric accuracy (i.e., correctly overlaid spine labels within the correct vertebral level in all cases) and did not introduce ambiguity in image interpretation.  The study shows LevelCheck to be a potentially useful means of decision support in spine surgery target localization and motivates translation to prospective clinical studies.

This study was recently highlighted in the publication Spine Surgery Today.  Read the full article here.

Read the full paper in Spine.



I-STARs at the 2017 SPIE Medical Imaging Conference

October 19, 2016

Eleven I-STARs will attend the 2017 SPIE Medical Image Conference in Orlando, FL from February 11-16, 2017 where they will present research in Image Registration, Cone-Beam CT, Image Reconstruction and Image-Guided Surgery.

A complete schedule of talks and posters –

Michael Brehler, Ph.D. –   “Atlas-based automatic measurements of the morphology of the tibiofemoral joint” (12 February 2017 • 3:30 – 3:50 PM)

Grace J. Gang, Ph.D. – “Joint optimization of fluene field modulation and regularization in task-driven computed tomography” (13 February 2017 • 2:40 – 3:00 PM)

Graduate student Sarah Ouadah –  “Task-driven orbit design and implementation on a robotic C-arm system for cone-beam CT” (14 February 2017 • 8:00 – 8:20 AM)

Alejandro Sisniega , Ph.D. – “Development and clinical translation of a cone-beam CT scanner for high-quality imaging of intracranial hemorrhage” (14 February 2017 • 9:00 – 9:20 AM)

Joseph Goerres, Ph.D. – “Deformable 3D-2D registration for guiding K-Wire placements in pelvic trauma surgery” (14 February 2017 • 11:10 – 11:30 AM)

Matthew W. Jacobson, Ph.D. –  “Geometric calibration using line fiducials for cone-beam CT with general, non-circular source-detector trajectories” (14 February 2017 • 8:20 – 8:40 AM)

Graduate student Michael D. Ketcha – “Fundamental limits of image registration performance:effects of image noise and resolution in CT-guided interventions” (14 February 2017 • 10:30 – 10:50 AM)

Graduate student Qian Cao – “High-resolution cone-beam CT of the extremities with a CMOS detector: task-based optimization of scintillator thickness” (15 February 2017 • 8:20 – 8:40 AM)

Masters student Michael Mow  – “Brain perfusion imaging using a reconstruction of difference approach for cone-beam computed tomography ”                                                    (15 February 2017 • 9:00 – 9:20 AM)

Aswin J. Mathews, Ph.D. –  “Experimental evaluation of dual multiple aperture devices for fluence field modulated x-ray computed tomography” in a poster presentation on (15 February 2017 • 5:30 – 7:00 PM)

Tharindu de Silva  Ph.D. – “C-arm positioning using virtual fluoroscopy for image-guided surgery” poster session on (15 February 2017 • 5:30 – 7:00 PM)


I-STARs at 102nd RSNA Meeting in Chicago

October 6, 2016

I-STARs present their research at the 102nd RSNA assembly and annual meeting in Chicago, Illinois.

Dr. Michael Brehler discussed “Quantitative Assessment of Trabecular Bone Microarchitecture Using High-Resolution Extremities Cone-Beam CT” on  Sunday November 27th  from 11:55-12:05pm.

Jeff Siewerdsen, PhD presented a talk entitled, Open Gantry Systems: Advances, Challenges, and New Applications on Sunday November 27th from 2:00-3:0 30pm.

Tharindu De Silva, PhD presented research on “Development and Clinical Translation of the “LevelCheck” Algorithm for Decision Support in Spine Surgery” at the Physics Tuesday Poster Discussion on Tuesday, Novmeber 29th from 12:15-12:45pm.

Dr. Jennifer Xu discussed “A Point-of-Care Cone-Beam CT System for Imaging of Intracranial Hemorrhage: Performance Characterization for Translation to Clinical Studies” on Wednesday, November 30th from 11:30-11:40am.

Matthew Jacobson, PhD presented his research on “Mobile C-Arm Cone-Beam CT: A New Prototype Incorporating Model-Based Image Reconstruction and Soft-Tissue Contrast Resolution” on Wednesday, November 30th from 11:40-11:50am.

Wojciech Zbijewski, PhD participated in an educational talk on Extremity CT, specifically MSK on Thursday, December 1st from 4:30-6:30pm.


Paper by Jen Xu: Image quality for a new cone-beam CT head scanner

September 16, 2016

A recent publication in Physics in Medicine and Biology entitled: “Evaluation of detector readout gain mode and bowtie filters for cone-beam CT imaging of the head”, reports evaluation of the efficacy and benefits of various detector gain modes and/or use of bowtie filters on the image quality (in terms of contrast and noise) in a Cone-Beam CT (CBCT) system, with application to high-quality imaging of low-contrast lesions in the head. The work develops a model of digitization noise as related to inherent additive electronics noise and panel gain mode, with applications to generalized analysis of the effects of gain mode and imaging dose on detective quantum efficiency analysis. Three bowtie filters of varying curvature and thickness were designed to evaluate tradeoffs in image quality from bowtie shape. The changes to dose distribution within the object imparted by bowtie filters was evaluated with a fast, GPU-based Monte Carlo simulation. The results from this evaluation were used in determination of the clinical protocols for a prototype CBCT scanner dedicated to imaging of acute intracranial hemorrhage.

This paper includes co-authors from Johns Hopkins Department of Biomedical Engineering (A. Sisniega, W. Zbijewski, H. Dang, JW. Stayman, JH. Siewerdsen), Department of Neuropathology (V. Koliatsos), Department of Neuroradiology (N. Aygun) and Carestream Health (DH. Foos, X. Wang).

J. Xu et al., Phys. Med. Biol. 61:5973 (2016)